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pentobarbital will lower the extent or effect of osilodrostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lower the level or impact of mifepristone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. CYP3A4 inducers haven't been researched, coadministration not advised by makerpentobarbit